Accurate determination of blood glucose concentration has a great significance in the prevention and treatment of diabetes as well as in the food processing and fermentation.
Glucose oxidase (GOx) modified electrodes play an important role in blood glucose detection by electrochemical methods. Enzyme-based sensors have disadvantages such as low enzyme stability and complicated immobilization.
To eliminate these disadvantages, non-enzymatic sensors with metal and metal oxide nanoparticles have been used. However, these sensors have some disadvantages such as poor sensitivity and selectivity and low catalytic activity. Some researchers eliminated these disadvantages by decorating the metal / metal oxide nanostructures on active carbon supports including carbon nanotubes (CNTs), graphene, etc.
Fe3O4 MNPs with good magnetic property are widely used for electrochemical biosensors and, in particular, they are also used for glucose detection as a direct non-enzymatic biosensor with no glucose oxidase.
Pak Wi Song, a section head at the Faculty of Chemical Engineering, has prepared an electrochemical sensing platform for glucose sensing by magnetic loading of Fe3O4/GO nanocomposites on graphite-epoxy composite electrode (GECE).
He characterized the Fe3O4/GO/GECE modified electrode by scanning electron microscopy (SEM), X-ray diffraction analysis (XRD) and cyclic voltammetry (CV).
The fabricated biosensor exhibited excellent electrocatalytic activity. The linear range for glucose is from 0.5 to 6.5mM with the detection limit of 268.5μM (S/N =3) and the sensitivity of 63.5mA/mM.
For more information, please refer to his paper “Magnetic Fe3O4/GO nanocomposite-modified graphite-epoxy composite electrode for high-performance glucose sensing” in “International Journal of Electrochemical Science” (SCI).
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